Pueraria Mirifica is a plant that contains certain active phytoestrogens including miroestrol and some types of isoflavones. These phytochemical substances are classified as phytoestrogen that have technical properties of cell rejuvenation.
There are some argues how miroestrol produced by this plant. Some scientists hypothesized that this active phytoestrogen just obtained from extracting the plant (root). However, other scientists suggested other natural substance that responsible to produce miroestrol - Deoxymiroestrol, that interacts with oxygen producing miroestrol.
Regardless how miroestrol is produced, the Thai folklore medicines has used this herb for long as a natural remedy for rejuvenating in aged women and men. Thereafter studies were intensively conducted to investigate the effect of P. Mirifica (starting from 1959) due to population-based evidences regarding to its therapeutic benefits. In fact, when they found the potency of this Thai miracle "Kwao Keur" herb, one of pharmaceutical companies patented it as Mirofirm™ to support their product lines, especially to aging skin products.
A study archived in Nature: 1960 Dec 3;188:774-7 concluded, P. mirifica contains a highly active phytoestrogen that closely mimics human estrogen." Interestingly, the estrogenic activities of miroestrol were more powerful than other botanical sources that rich in phytoestrogen such as Black Cohosh, Soy, or Red Clover.
As aging, menopause, and childbirth are common factors that makes vaginal walls and muscles become thin and weak, then estrogenic activities of P. Mirifica are certainly useful for those who want to overcome vaginal atrophy that causes painful sex or dyspareunia, itching, burning sensation, or thin vaginal walls, including rejuvenate their pelvic muscles for better strength of contraction. Similarly to Oak Gall and Witch Hazel - other potent herbs with strong phytoestrogens content and listed in the medical literature with instant tightening outcomes due to its tannin content that have astringent property, P. Mirifica also has some clinical evidences related to their estrogenic activities that can help women with estrogen deficiency and its impacts even though it can't give instant tightness outcomes.
A study conducted by researchers of the National Research University-Khon Kaen University, Thailand, archived in Fitoterapia (2012) revealed miroestrol to be effective as "alternative hormone replacement therapy of E2" due to its ability in maintaining estrogen deficiency associated to rapid progression of osteoporosis. (Fitoterapia, 2012 Dec;83(8):1687-92)
Another study conducted by researchers from Dept. of Biology, Faculty of Science of Chulanlongkom University, also concluded, "P. mirifica could be applicable for preventing, or as a therapeutic for the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men." (Front Med. 2012 Mar;6(1):8-21)
In addition to miroestrol, it also contains Chalcone or Chalconoid. It is natural phenols that can accelerate the absorption of their phytochemical contents. It is vitamin P classified as flavonoids due to its ability on the permeability of vascular capillaries but not classified as alcohol. That being said, since this plant contains miroestrol and other active phytoestrogens, therefore, the absorption of these active substances can become faster.
Why this herb becomes "strong competitor" to other herbs that have aggressive estrogenic activities like Witch Hazel and Oak gall which also can can make your vagina tighter by rejuvenating your genital organs, as well as eliminate vaginal dryness?
In addition to miroestrol and its natural phenols, at least 17 phytoestrogens have been identified on this plant which also potential with antioxidant properties. In fact, their phytoestrogen can even inhibit the growth of tumor cells. A little 'minus point' of P. Mirifica compared to other potent herbs like Oak Gall and Witch Hazel is, P. Mirifican cannot make your vagina tighter fast or even instantly, keep the composition of collagen and elastin beneath vaginal walls and lips maintained, and increase blood flow to your genital organs (hence enhance your sex drive and stimulate fluid secretion). This is because P. Mirifica has no tannin content. The tightening outcomes to the vaginal walls and muscles relies on their phytoestrogen contents, especially to its miroestrol. Read this page for more detail.
Potential Side Effects and Toxicity
As far as human trials, doses ranging from 25 mg to 100 mg in open-label studies found no side effects or toxicities for 6 months of following-up.
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